Tang, X. Q., Bi, H., Feng, J. Q., and Cao, J. G. Effect of curcumin on multidrug resistance in resistant human gastric carcinoma cell line SGC7901/VCR. Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia. Mechanism(s) of turmeric-mediated protective effects against benzo(a)pyrene-derived DNA adducts. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Chand S, Hair C, Beswick L. A rare case of turmeric-induced hepatotoxicity. Imam Z, Khasawneh M, Jomaa D, Iftikhar H, Sayedahmad Z. Drug induced liver injury attributed to a curcumin supplement. Efficacy and safety of curcumin in treatment of intestinal adenomas in patients with familial adenomatous polyposis. The effects of a traditional drug, tumeric (Curcuma longa), and placebo on the healing of duodenal ulcer. The cells were then incubated for 20 min in a 5% CO2 incubator at 37°C. Subsequently, cells were washed with PBS 3 times and 100 μL of the JC‐1 (5,5′,6,6′‐tetrachloro‐1,1′,3,3′ tetraethylbenzimidazolylcarbocyanine iodide; Cayman Chemical, Michigan, USA). Cells were plated in 12‐well plates at a density of 1 × 105 cells/well and incubated at 37°C overnight. We obtained an effective preparation of curcumin (THERACURMIN),12 a nano‐particle colloidal dispersion with improved oral bioavailability (THERACURMIN, Theravalues, Tokyo, Japan). Prostate cancer is currently the second leading cause of cancer death among males. Correspondence, Hisamitsu Ide, Department of Urology, Dokkyo Medical University Saitama Medical Center, Koshigaya, Japan. Therefore, it may be safe to conclude that 1000mg of Curcumin and 5-10mg of Bioperine will not reach the threshold to inhibit testicular 17beta-hydroxysteroid dehydrogenase 3. Furtheremore, The potencies of inhibiting 17b-HSD3 in human testis microsomes for curcumin was 67.3 uM . Curcumin has also been found to inhibit testicular 17beta-hydroxysteroid dehydrogenase 3 potentially having a negative impact on testicular testosterone synthesis. Now I assume Men & Women metabolise Estrogen in the same manner, therefore one can extrapolate and assume a similar outcome for serum Estrogen levels in Men. However, grapefruit juice, a potent CYP3A4 inhibitor was actually shown clinically to reduce endogenous serum Estrogen levels in Postmenopausal Women . Estrogen is a substrate of CYP3A4 and logically I originally concluded that inhibiting CYP3A4 will impair Estrogen clearance from the body, potentially leading to downregulation of the HPTA and lowering of testosterone. I personally am using a formula with 5mg of Bioperine with 1000mg of Curcumin as I am currently taking prescription drugs and want to be on the safe side. Deeb D, Xu YX, Jiang H, et al. Curcumin (diferuloyl-methane) enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in LNCaP prostate cancer cells. Clinical study results have directly linked curcumin to testosterone. Interestingly, when rats orally consumed concentrations of 200mg/kg of Curcumin (which is a massive dose), there was no change in cellular DHT levels ! In vitro and pilot clinical studies showed that curcumin can inhibit testosterone metabolism and enhance its systemic levels. (A) Testosterone and (B) dihydrotestosterone levels in prostate tissues of transgenic adenocarcinoma of… Effects of curcumin on the growth of prostate cancer cell lines. After 1-month oral administration of curcumin, Aldo-Keto reductase 1C2 (AKR1C2) expression was elevated. To evaluate the effect of curcumin on the proteins involved in steroidogenesis in LNCaP prostate cancer cells (Figure 3C), we examined these proteins expression using western immunoblotting after treatment with various concentrations of curcumin. Multicenter randomized phase II study comparing docetaxel plus curcumin versus docetaxel plus placebo in first-line treatment of metastatic castration-resistant prostate cancer. A strength of this systematic review is the inclusion of only randomized controlled trials investigating the effect of a single herb on testosterone concentrations in men. Three studies were randomized controlled trials (39, 48, 54) and 1 study was a randomized, double-blind, placebo-controlled trial (61). Five studies were randomized, double-blind, placebo-controlled trials (42, 57, 58, 63, 64) and one was a randomized, double-blind, placebo-controlled crossover study (53). Therefore, the aim of this systematic review was to summarize and critically evaluate randomized controlled trials conducted to assess the efficacy of single herbal ingredients on testosterone concentrations, in addition to their fractions or binding proteins, in men. The aim of this systematic review was to summarize and critically evaluate randomized controlled trials published on the efficacy of single herbal ingredients on testosterone concentrations, in addition to its fractions or binding proteins, in men (≥18 y).
