There is suggestive evidence that injection oftestosterone into some strains of female mice increases their susceptibility to hepatoma. Regularmonitoring of serum calcium concentrations is recommended in these patients. Gynecomastia may develop and persist in patients being treated withandrogens, including ANDRODERM, for hypogonadism. Edema, with or without congestive heart failure, may be a seriouscomplication in patients with preexisting cardiac, renal, or hepatic disease seeADVERSE REACTIONS. If you miss your dose of topical testosterone, apply it as soon as you remember. Always check with your health care provider. Tell your health care provider if you have any of the following. Tell your health care provider if you have any worsening prostate symptoms, such as having a hard time peeing or a weak flow, more frequent peeing, or having an urgent need to pee. Tell your health care provider if you have an enlarged prostate, or BPH. If you have any questions, talk to your health care provider. If you become pregnant, contact your health care provider right away. You are encouraged to report negative side effects of prescription drugs to the FDA. It is not known if Androderm is safe or effective to treat men who have low testosterone due to aging. The one patient that was titrated to 6 mg/day discontinued from the study for a non-safety related reason. Patients applied an ANDRODERM 4 mg/day system around 10 p.m. Patients had previously been on stable therapy of ANDRODERM 5 mg; Androgel® 2.5 g, 5 g, 7.5 g or 10 g; or Testim® 2.5 g or 5 g daily before switching to ANDRODERM 4 mg/day. ANDRODERM 2 mg/day and 4 mg/day were studied in a trial designed to evaluate the use and titration of 2 mg/day and 4 mg/day systems in a clinic setting of 40 men with hypogonadism. The systemic exposure to ANDRODERM was similar following applications with or without showering 3 hours after application. Topical testosterone comes in several forms, including a gel or liquid that is applied to the skin. RxList does not provide medical advice, diagnosis or treatment. Androderm is used to treat adult males who have low or no testosterone due to certain medical conditions. Androderm is a prescription medicine that contains testosterone. In these trials, ANDRODERM produced average morning serum testosterone concentrations within the normal reference range in 92% of patients. The hormonal effects of ANDRODERM 2.5 mg/day system as a treatment for male hypogonadism was demonstrated in four open-label trials that included 94 hypogonadal men, ages 15 to 65 years. In separate clinical studies using the ANDRODERM 2.5 mg/day system, 1% used 2.5 mg daily, 93% of patients used 5 mg daily, and 6% used 7.5 mg daily. Long-termtherapy with intramuscular testosterone enanthate has produced multiple hepaticadenomas. An increase in red blood cell mass may increase therisk of thromboembolic events. Discontinue testosterone therapy if the hematocrit becomeselevated. Discard systems in household trash in a manner that preventsaccidental application or ingestion by children, pets or others. The drug reservoir may be burst by excessivepressure or heat. It is important to use this medication exactly as prescribed by your doctor. Place the used patch in the package that the new patch has been taken from, and discard it. After use, remove the patch and fold it so that the adhesive side is on the outside. If a patch becomes loose, smooth it down again by rubbing over the edges of the patch. Out of 36 patients who entered the study, 31 (86%) patients remained on the 4 mg/day dose, 4 (11%) were titrated downward to 2 mg/day, and 1 (3%) was titrated upward to 6 mg/day based on the Day 8 testosterone concentrations. Androderm (testosterone transdermal system) is designed to deliver testosterone continuously for 24 hours following application to intact, non-scrotal skin (e.g., back, abdomen, thighs, upper arms). Our Androderm (testosterone transdermal system) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. You should always consult your doctor or other healthcare professional before taking any medication.
